Important DropKitsTM Safety Information

Bupropion/ Naltrexone/Topiramate

BUPROPION / NALTREXONE / TOPIRAMATE tablets should be taken while also improving your diet and lifestyle to achieve your target weight. If you start taking an SSRI or medication for ADHD, stop taking BUPROPION / NALTREXONE / TOPIRAMATE pills and notify your doctor immediately.

POTENTIAL BENEFITS

  • Weight Loss Support: Helps to reduce hunger, manage cravings, and enhance satiety (feeling full).
  • Mood Regulation: Bupropion may improve motivation and energy levels, aiding in sustaining lifestyle changes.
  • Appetite Control: Topiramate may reduce appetite and support weight management.
  • Craving Reduction: Naltrexone may help curb cravings, especially for certain foods.

POTENTIAL RISKS AND WARNINGS

Common Side Effects:

Nausea, headache, dizziness, insomnia, dry mouth, and tingling in the fingers or toes (common with Topiramate). These effects may lessen as your body adjusts to the medication.

Serious Side Effects

Elevated blood pressure or heart rate. Seizures, especially in patients with a seizure history or taking other medications that lower the seizure threshold. Vision problems, such as blurry or double vision (associated with Topiramate). Memory issues or difficulty concentrating (associated with Topiramate). Mental Health Changes: Increased anxiety, mood swings, or depression. Notify your doctor immediately if you experience severe mental health changes.

INTERACTION RISK:

Do not use with alcohol, opioids, or other medications affecting the central nervous system. Avoid use if taking SSRIs, ADHD medication, or other drugs that may interact with Bupropion, Naltrexone, or Topiramate.

Who Should Not Use Bupropion/Naltrexone/Topiramate:

  • Individuals currently taking any of the following medications: Amitriptyline, Aripiprazole (Abilify), Bupropion (Wellbutrin), Citalopram (Celexa), Cyclobenzaprine (Flexeril), Duloxetine (Cymbalta), Escitalopram (Lexapro), Haloperidol (Haldol), Lurasidone (Latuda), Mirtazapine (Remeron), Olanzapine (Zyprexa), Paroxetine (Paxil), Quetiapine (Seroquel), Risperidone (Risperdal), Sertraline (Zoloft), Tramadol (Ultram), Trazodone (Desyrel), Venlafaxine (Effexor), Ziprasidone (Geodon).
  • Those with uncontrolled blood pressure exceeding 160/110.
  • Individuals with cirrhosis, liver problems, or liver failure.
  • Those with a history of kidney stones
  • Those with metabolic acidosis.
  • Individuals at risk of dehydration.
  • Those with Cognitive Impairment.
  • Individuals using carbonic anhydrase inhibitors.
  • Those allergic to naltrexone, bupropion, topiramate or opiates.
  • Individuals currently being treated with opiates or using opiates recreationally.
  • Those with a history of bipolar disorder, seizures, glaucoma, heart failure, or heart attack.
  • Individuals with a history of severe diagnosed depression, any type of eating disorder, self-harm, suicidal ideation, or attempts.
  • Those with a history of mental health hospitalization.
  • Individuals who are currently pregnant or breastfeeding.

WHEN TO CONTACT YOUR DOCTOR

  • Severe or worsening side effects.
  • Concerns about medication interactions.
  • Unexpected symptoms like severe dizziness, confusion, vision changes, or rapid heartbeat.

WE ENCOURAGE YOU TO NOTIFY YOUR PRIMARY CARE DOCTOR ABOUT YOUR WEIGHT LOSS PROGRAM.

Maintaining open communication with your healthcare team ensures the safest and most effective weight loss journey.

Bupropion/ Naltrexone

BUPROPION / NALTREXONE tablets should be taken while also improving your diet and lifestyle to achieve your target weight. If you start taking an SSRI or medication for ADHD, stop taking BUPROPION / NALTREXONE pills and notify your doctor immediately.

POTENTIAL BENEFITS

  • Weight Loss Support: Helps to reduce hunger and manage cravings.
  • Mood Regulation: Bupropion may help improve motivation and energy levels, which can aid in sustaining lifestyle changes.
  • Metabolic Boost: Naltrexone may help curb cravings and support weight management.

POTENTIAL RISKS AND WARNINGS

Common Side Effects:

Nausea, headache, dizziness, insomnia, and dry mouth. These effects may lessen as your body adjusts to the medication.

Serious Side Effects:

Elevated blood pressure or heart rate. Seizures, especially in patients with a seizure history or taking other medications that lower the seizure threshold.

Mental Health Changes:

Increased anxiety, mood swings, or depression. *Notify your doctor immediately if you experience severe mental health changes.

INTERACTION RISK:

*Do not use with alcohol, opioids, or other medications affecting the central nervous system.

*Avoid use if taking SSRIs, ADHD medication, or other drugs that may interact with Bupropion or Naltrexone.

Who Should Not Use Bupropion/Naltrexone:

  • Individuals currently taking any of the following medications: Amitriptyline, Aripiprazole (Abilify), Bupropion (Wellbutrin), Citalopram (Celexa), Cyclobenzaprine (Flexeril), Duloxetine (Cymbalta), Escitalopram (Lexapro), Haloperidol (Haldol), Lurasidone (Latuda), Mirtazapine (Remeron), Olanzapine (Zyprexa), Paroxetine (Paxil), Quetiapine (Seroquel), Risperidone (Risperdal), Sertraline (Zoloft), Tramadol (Ultram), Trazodone (Desyrel), Venlafaxine (Effexor), Ziprasidone (Geodon).
  • Those with uncontrolled blood pressure exceeding 160/110.
  • Individuals with cirrhosis, liver problems, or liver failure.
  • Those allergic to naltrexone, bupropion, or opiates.
  • Individuals currently being treated with opiates or using opiates recreationally.
  • Those with a history of bipolar disorder, seizures, glaucoma, heart failure, or heart attack.
  • Individuals with a history of severe diagnosed depression, any type of eating disorder, self-harm, suicidal ideation, or attempts.
  • Those with a history of mental health hospitalization.
  • Individuals who are currently pregnant or breastfeeding.

WHEN TO CONTACT YOUR DOCTOR

  • Severe or worsening side effects.
  • Concerns about medication interactions.
  • Unexpected symptoms like severe dizziness, confusion, or rapid heartbeat.

WE ENCOURAGE YOU TO NOTIFY YOUR PRIMARY CARE DOCTOR ABOUT YOUR WEIGHT LOSS PROGRAM.

Maintaining open communication with your healthcare team ensures the safest and most effective weight loss journey.

Off-Label Use

Bupropion is an FDA-approved treatment for major depressive disorder, but healthcare providers may prescribe it for other purposes as deemed appropriate within medical practice.

Topiramate is approved by the FDA for treating partial-onset seizures and primary generalized tonic-clonic seizures in individuals 2 years and older, as well as for use with other medications to treat these and Lennox-Gastaut syndrome-related seizures. Additionally, it is approved for migraine prevention in adults and adolescents aged 12 and older. Off-label, it is sometimes prescribed to assist with weight loss and weight management in adults.

Naltrexone is FDA-approved to treat opioid and alcohol use disorders by helping patients avoid relapse and reduce cravings. It may also be used off-label to support weight loss and long-term weight management in adults.

*It is legal and common for physicians to prescribe a drug for off-label use when it is determined to be medically appropriate. In fact, according to the Agency for Healthcare Research and Quality, one in five prescriptions today are for off-label use. Find out the FDA's official policy for 'off-label' medications: https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label

Compounded medications are not subject to FDA approval.

You can find out more about the FDA's opinion regarding compounded medications and their risks and benefits by going to the following link: https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers

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1 In a clinical trial , the participants with BMI 30 or more, or 27 or more with at least one weight-related condition, the average participant lost 20.9% of body weight during the 72-week trial.

2 In a clinical trial , the participants with BMI 30 or more, or 27 or more with at least one weight-related condition, the average participant lost 14.9% of body weight during the 68-week trial.

Weight loss study results like the above may vary for oral semaglutide due to potential differences in formulation and dosing. Licensed medical professionals, including Brightmeds-affiliated physicians, can prescribe oral semaglutide after medical evaluation to aid in weight management. For personalized guidance, we recommend consulting with a healthcare provider.

*Important Notice: The recognized brand name medication approved by the FDA, Zepbound™ and Mounjaro® is manufactured by Eli Lilly and Company™, and Wegovy® and Ozempic® is manufactured by Novo Nordisk™. We do NOT manufacture this medication and have no direct affiliation with either Eli Lilly and Company™or Novo Nordisk™. Upon patient request, our partner pharmacies can supply the above mentioned brand name medication, however they are subject to availability.

Regarding compounded medications, our company works with sterile compounding pharmacies. These facilities undergo strict inspections, but because the compounded pharmaceuticals they produce are made according to a prescription from a specific practitioner for a particular patient, they are not FDA-approved. It might be challenging to directly compare the results and risk profiles of FDA-approved and compounded pharmaceuticals due to differences in strength, dose, and other factors.  The medical judgment of a licensed clinician, based on a telemedicine interaction and medical history, determines the prescription of any compounded medication.

100% money back guarantee if your prescription is not approved; brightmeds.com does not directly offer medical or pharmacy services. We partner with medical professionals who use HIPAA-compliant platforms to deliver services. This website’s content is meant only as a source of information; it should not be used as a substitute of expert medical advice, evaluation, or care. Please contact your doctor if you have any questions or concerns regarding your health.

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